Here’s Kevin Richter taking you through the whole process of using DAZ Studio, a bit of Maya, and Photoshop Extended to make a finished digital comic. Kevin creates this as a regular comic-strip for the biggest newspaper in the UK, The Sun. It’s a fine (if a little dizzying) 8-minute speed-run…
If you need good comic book fonts (vital in getting the right look), try Blambot which has a strong range of free fonts as well as paid-for. Also Comiccraft, and Fonts.com. Free speech-balloon fonts are Komika Bubble (komikabb.ttf), and TalkTalk (talk.ttf).
As for comics layout software, the best and simplest for most people is Comic Life Deluxe